First Drug for Desmoid Tumors: ‘Impressive’ Data for Nirogacestat

First Drug for Desmoid Tumors: ‘Impressive’ Data for Nirogacestat

PARIS — Desmoid tumors are rare, locally aggressive, soft-tissue tumors for which there is no approved systemic therapy — but a novel drug may become the first. Nirogacestat, under development by Connecticut-based SpringWorks Therapeutics, is an oral, selective, small-molecule gamma secretase inhibitor (GSI) that targets the Notch signaling pathway, which is involved in cell differentiation. … Read more

Anne Heche cause of death: Star dies after severe anoxic brain injury sustained in crash

Anne Heche cause of death: Star dies after severe anoxic brain injury sustained in crash

Anne Heche has died aged 53 of horrific injuries sustained during a high-speed crash last week. The actress and mother-of-two has been on life support to “determine if her organs are viable” for donation. Confirming the devastating news of her death, a representative for her family told People that, while Heche has been declared legally … Read more

Aerosmith singer Steven Tyler enters drug rehab

Aerosmith singer Steven Tyler enters drug rehab

The legendary rock band has been forced to cancel a string of shows as singer Steven Tyler checks into rehab for drug issues. Rocker Steven Tyler has relapsed and “voluntarily” checked into rehab, his Aerosmith bandmates revealed. “As many of you know, our beloved brother Steven has worked on his sobriety for many years,” the … Read more

California authorities seize nearly 100 pounds of fentanyl – WKRC TV Cincinnati

California authorities seize nearly 100 pounds of fentanyl – WKRC TV Cincinnati

California authorities seize nearly 100 pounds of fentanyl  WKRC TV CincinnatiView Full Coverage on Google News