The crash occurred in an inbound lane of Kings Way near the Citylink off ramp just after 1.30pm.
The person died at the scene and is yet to be identified.
The exact circumstances surrounding the collision are being investigated.
Motorists are being advised to expect significant delays in the area with three inbound lanes closed on Kings Way.
Anyone with information, dashcam or CCTV footage of the incident is urged to contact police.