NFL odds, lines, picks, spreads, best bets, predictions for Week 5, 2022: Model high on Titans, Jaguars

The Philadelphia Eagles are the only team with an unblemished record entering the Week 5 NFL schedule. However, the Eagles will need to keep winning if they want to stay atop the NFC West standings after the Cowboys (3-1) and Giants (3-1) continued their strong starts to the season. Philadelphia will travel across the country to play the Arizona Cardinals on Sunday. According to the latest Week 5 NFL odds from Caesars Sportsbook, the Eagles are five-point favorites on the road, one of the larger NFL spreads of the week.

Other notable Week 5 NFL Vegas odds include Cowboys vs. Rams (-4.5), Steelers vs. Bills (-14) and Bengals vs. Ravens (-3). Which spreads, totals and money lines should you target in your Week 5 NFL bets? All of the Week 5 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting advice and predictions you need to make the best Week 5 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2022 NFL season on an incredible 139-103 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 5 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 5 NFL predictions

One of the model’s strongest Week 5 NFL picks is that the Titans (-2.5) cover against the Commanders in almost 60% of simulations. Tennessee is coming off an important 24-17 win on the road against the Indianapolis Colts despite not scoring a single point in the second half. Tennessee got off to a blistering start behind running back Derrick Henry, who finished the game with 22 carries for 114 yards and a touchdown.

Henry has now scored a touchdown in three consecutive games. Meanwhile, the Commanders have been disappointing after beating the Jaguars in their season-opener, losing their last three games. Washington’s defense is giving up 26.8 points per game this season, which ranks 29th. Plus, the Commanders are just 8-16 in their last 24 games at FedEx Field. That’s one of the reasons why SportsLine’s model projects the Titans will cover the spread nearly 60% of the time. See which other teams to pick here.

Another one of its Week 5 NFL predictions: The Jaguars (-7) cover at home in a divisional matchup against the Texans. Jacksonville has played just one home game thus far, a 24-point shutout win over the Colts. Jacksonville ranks third with a plus-38 point differential, trailing only arguably the top two teams in the NFL, the Bills and Eagles.

The Jags fell to Philly in Week 4 thanks to wet conditions that resulted in four lost fumbles by Trevor Lawrence. That was certainly an outlier of a game since Lawrence had just three combined lost fumbles over his previous 17 games. The Jags have a top-10 offense and a top-10 defense, while Houston is in the bottom half of the league in both categories. Jacksonville is projected to win by double-digits and to cover in well over 50% of simulations. The model also has the Under (44.5) hitting well over 50 percent of the time. See which other teams to pick here.

How to make Week 5 NFL picks 

The model has also made the call on who wins and covers in every other game on the Week 5 NFL schedule, and it also says an underdog delivers a huge upset. You can only get every pick for every game at SportsLine.

So what NFL picks can you make with confidence? And which underdog delivers a huge upset? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $7,000 since its inception, and find out.

Week 5 NFL odds, lines, spreads

Get full NFL picks at SportsLine

Sunday, Oct. 9

Giants at Packers (-8, 41)

Featured Game | Green Bay Packers vs. New York Giants

Steelers at Bills (-14, 46.5)

Featured Game | Buffalo Bills vs. Pittsburgh Steelers

Chargers at Browns (+2.5, 47.5)

Featured Game | Cleveland Browns vs. Los Angeles Chargers

Texans at Jaguars (-7, 43.5)

Featured Game | Jacksonville Jaguars vs. Houston Texans

Bears at Vikings (-7, 44)

Featured Game | Minnesota Vikings vs. Chicago Bears

Lions at Patriots (-3, 45.5)

Featured Game | New England Patriots vs. Detroit Lions

Seahawks at Saints (-5.5, 46)

Featured Game | New Orleans Saints vs. Seattle Seahawks

Dolphins at Jets (+3.5, 46)

Featured Game | New York Jets vs. Miami Dolphins

Falcons at Buccaneers (-9, 48)

Featured Game | Tampa Bay Buccaneers vs. Atlanta Falcons

Titans at Commanders (+2.5, 42.5)

Featured Game | Washington Commanders vs. Tennessee Titans

49ers at Panthers (+6.5, 39)

Featured Game | Carolina Panthers vs. San Francisco 49ers

Eagles at Cardinals (+5, 49)

Featured Game | Arizona Cardinals vs. Philadelphia Eagles

Cowboys at Rams (-5.5, 42.5)

Featured Game | Los Angeles Rams vs. Dallas Cowboys

Bengals at Ravens (-3, 48.5)

Featured Game | Baltimore Ravens vs. Cincinnati Bengals

Monday, Oct. 10

Raiders at Chiefs (-7, 51)

Featured Game | Kansas City Chiefs vs. Las Vegas Raiders