The event came amid a wave of protests against the vaccine mandate in New York City and across the country.
An independent journalist took to Twitter to record a clash between the two sides, with one person calling the anti-vaccination-mandated protesters “Nazi scum.”
America First protesters were also seen shout “f — Antifa” during the protest.
“Stop acting tough, bro,” was one person… heard yelling at an America First protester at the event.
Additionally video of the protest shows police officers forming a barricade between the two sides.
An America First spokesperson told Fox News that the group was protesting its opposition to vaccine mandates.
An Antifa representative did not respond to Fox News.
It was at least the second time in as many weeks that the COVID vaccine mandate has drawn protesters to Grace Mansion.
Protesters gathered outside the house on Oct. 28 to protest the Democratic mayor Bill de Blasio‘s vaccine mandate, requiring first responders to receive at least one dose of the vaccine by Oct. 29 or take pay-as-you-go leave.
Firefighters from New York City took part in the October 28 protest.
“We got through this pandemic,” an FDNY officer in his 50s, who asked for anonymity because of department policy, told Fox News at the time. “Many of us got sick during that time. There was no vaccination. We were endangering our families. We were endangering ourselves.”
The city’s famous Times Square was overrun by thousands of protesters against the COVID-19 vaccine mandate in September.
Similar demonstrations of anti-vaccine mandates have erupted in other major US cities that have adopted policies like New York City’s.
Hundreds of protesters showed up in downtown Los Angeles just last week.
The New York City Police Department did not respond to a request for comment from Fox News about Saturday’s protests.
Fox News’ Pilar Arias, Rebecca Rosenberg and Peter Aitken contributed to this report.