Why ‘breakthrough’ infections shouldn’t be a surprise even after a COVID-1 after vacation

Recently Morbidity and death weekly report (MMWR), Provides researchers at the US Centers for Disease Control (CDC) The first wide volume The number of so-called “success infections” – COVID-19 infections that occur in people vaccinated against this disease.

Of the more than 100 million people who received the full vaccine in the U.S. during the study period from January to April 300 – which means two weeks behind their last vaccine dose, 10,262 cases of SARS-Cove-2 infection were reported by the state and the local health department at the CDC. Professor of Medicine in the Infectious Diseases Division of Emory University, Dr. Carlos del Rio says it only works on 0.01% of people vaccinated with certain infections. “For me, it’s just reassuring evidence that vaccines really do work.”
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No vaccine is 100% effective in protecting people from infection. And in fact, three vaccines have recently become official in US dollars Pfizer-Biotech, Modern And Johnson and Johnson-JohnsonWe are authorized based on their ability to protect people against the symptoms of COVID-19, not infection. But in the months since the vaccines were made, scientists have documented that the rate of infection is lower in people who have been vaccinated. In the past MMWRPublished in March, CDC Reported In a study of nearly 1,000,000 health care workers, two mRNA vaccines developed by Pfizer-Biotech and Modern were 0% effective in preventing people from contracting SARS-COV-2.

And that safety is confirmed by a very large population of people by the current report. Of the 101 million people vaccinated, 27% were successfully infected with COVID-1, about 10%, or 5,995 cases were found to have no symptoms, hospitalization, and 2%, or 1,160 people died. And of those who were hospitalized, about a third were admitted to some hospital Others More than COVID-19, and of those dead, about a fifth died of anything other than COVID-19.

“At the end of the day, I think that’s pretty good news,” says Del Rio. “And when success transitions, they usually don’t have serious clinical consequences. So I think in general it’s surprisingly reassuring. ”

Professor of Pediatrics, Epidemiology and Population Health at Stanford University. Bonnie Maldonado and members of the CDC committee agree to recommend a review of the vaccine. “Obviously, I think the numbers are amazing. These are miracle vaccines, with over 0% efficacy in clinical trials, 0.01% success infection rate, and almost no serious illness in 100 million people. It’s about the best information I can expect, ”she says.

CDC data explored to some extent what role new forms of SARS-CoV-2, which can easily spread among humans and cause more serious illness, play a role in success infections. Researchers have shown that genetically modified viruses are only successful in% of cases, although the data are not strong. But so far, it shows that less than half of the infections can be detected in more common variants, B.1.1.7 (a. Identified in the UK), Contributes a quarter of the transition to the newly identified version from California. But overall the percentage of infections is small, the immunity created by the vaccine still seems to be enough to prevent infection with these forms, and, if infected, in many cases lead to less serious diseases.

The authors note that the reported infection may be of a lesser importance than the actual success infections, because the reported vol is voluntary, and because many positive people may not feel the symptoms so there is no testing and diagnosis. Yet, based on the experience of other vaccines, public health experts expect this rate to remain low, with the COVID-19 vaccine influencing the virus to determine how effective it is in producing antibodies and long-term immunity.

As a result of these new facts, the CDC has told states and local health departments that they no longer have to report all cases of infection, and instead of notifying the CDC when these events result in hospitalization, serious illness or death. “These [cases] CDC Director Dr. Rochelle Walensky said in a press conference addressing the change.

Maldonado says there is no added value in asking for a transition to all success, especially as many appear to appear without any symptoms. She says the safety of the vaccine can be lost for whatever reason when working as a canary in a coal mine, as a result of hospitalization or death.

This, presumably, can only be the result of the passage of time. “By the end of this year, early people will have been vaccinated in about a year, and we need to rethink what is reported and what is not,” says Maldonado. “Because then the question is, are we going to lose immunity a year out?” She says state and local health departments will continue to track all new COVID-1 cases – not just small ones reported to the CDC. If cases continue to go up, health experts can check the data to see if vaccinated people appear to be more likely to become infected, and if so, whether variants may be responsible.

Maldonado says the only concern right now is about vaccinated people. Where new infections are starting and spreading for success cases. “This vaccine is 0% effective if you don’t get it,” she says.




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