DNA vaccines for COVID-19 are effective in mice, hamsters

A color scanning electron micrograph of the SARS-CoV-2 virus. Credit: NIAID

Currently available COVID-1 vaccines rely on mRNA kits to teach the human immune system to recognize the SARS-CoV-2 virus. Now, report within the investigators PLOS Neglected tropical diseases Successful development of a vaccine has been reported that uses DNA encoding the spike protein of the virus instead.

Both DNA and mRNA vaccines use the genetic material encoding part of the virus to reflect immunity, DNA vaccines can often be produced quickly and at low cost and can be transported without the need for cold temperatures. Recent clinical trials have indicated that DNA vaccines are safe and effective in treating infections including HIV 1, GK virus, Ebola virus and influenza virus.

In the new work, Shih-Zhen Liu and Hisin-Wei Chen National Institute of Health Research, Taiwan, and colleagues developed a vaccine that uses DNA to detect SARS-COV-2 spike proteins. To avoid low delivery of DNA to cells that often appear through DNA vaccines, the team distributed DNA vaccines with electrophoresis.

Researchers have shown that mice and hamsters vaccinated with new DNA vaccines develop long-lasting antibodies against the SARS-COV-2 spike protein. Those antibodies were vaccinated weeks later but levels remained relatively high at week 20. Ham received two vaccines a week later and appeared in COVID-1 weeks later. Weight and low viral RNA in their lungs compared to animals that are not vaccinated.

“The DNA vaccine is thermally stable which does not require a cold chain and it can raise high levels of long-lasting neutral antibody titers against SARS-COV-2,” the author adds. “The DNA vaccine provides protective efficacy against SARS-COVID-2 infection in Syrian hamsters, a sample of critically infected animals with COVID-1 disease.”

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More info:
Chai KM, Tzeng TT, Shen KY, Liao HC, Lin JJ, Chen MY, et al. (2021) DNA vaccines induce protective immunity in hamsters against SARS COV-2 infection. Also say PLoS Negl 1 (()): e0009374. doi.org/11/13711/magazine.punt0003 3.

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DNA vaccines for COVID-19 effective in mice, hamsters
Retrieved May 2, 2020
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