German scientists say they may help improve vaccines to prevent blood clots

A team of German scientists believed in why they did it Some people gave estrogen And Johnson & Johnson vaccines Blood clots develop against Covid-1 against – and claim that they can tell manufacturers how to improve its vaccine.

The main thing is the adenovirus – the common cold virus that is used to send coronavirus spike proteins into the body, says Rolf Marshleck, a professor at Goethe University in Frankfurt, and his colleagues. The mRNA vaccines developed by Pfizer / Bioentech and Modern do not use this distribution system and have not been shown to cause bleeding.

Blood clots are rare but problematic in younger age groups who are at higher risk of clots and are less likely to develop severe covidar disease. The UK is now offering a choice of vaccines to anyone under the age of 400, where available. There have been 100 million cases in the UK, of which 330 million people have been diagnosed AstraZeneca Vaccine

Scientists In print Friends who haven’t been to the review say the problem is that the adenovirus enters the nucleus of the cell instead of the cellular fluid, where the virus normally makes proteins.

β€œThe adenovirus life cycle involves the infection of cells … adenovirus DNA penetration into the nucleus, and later gene transcription by host transcription machinery,” they write.

“And the real problem is this: a viral piece of DNA … not adapted to transcription inside the nucleus.”

Within the cell nucleus, parts of the spike protein separate or divide. These mutants form pieces of protein that float in the body and can rarely move blood clots, scientists believe.

Prof Marshall Lake says vaccines can be redesigned to avoid problems. J&J is already in touch with him, he told the Financial Times.

The company “is now looking to optimize its vaccine,” he told the newspaper. “With the data we have on hand, we can tell companies how to change these sequences, coding for spike proteins that prevent unexpected spice reactions.”

He had not yet spoken to AstraZeneca, he said. The company was not in contact, “but if they do, I can tell you what I can do to make a better vaccine,” he told FT.

However, other scientists have other theories, and Marshall’s explanation of adverse events is still hypothesized, which remains to be researched by other experts.

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